Diário de Biologia Vetorial

Incidence, Risk factors and clinical outcomes of patients with hypermucoviscoid klebsiella in tertiary intensive care unit

Vimal Bhardwaj

This study was conducted at department of MICU at a tertiary care hospital between January 2018 and December 2018. A standardized proforma
was prepared and data was collected, which includes basic demographics of the patients, co-morbidities, clinical details and mortality. This study was
approved by the Institutional Review Board and Ethics Committee. Results: A total of 165 patients (males, 123; 74.5%) had Klebsiella pneumoniae
infection during the study period, out of whom 32 was hvKP (19.4%). The mean age was 53.1 ± 16.8 years. Among the 32 hvKP patients, 22 (68.8%)
were hospital acquired infection (HAI) and 10 were (31.2%) community acquired infection. The overall mortality rate of hvKP infection was 56.2%
(18/32). The incidence of mortality rate was similar in patients having pan-drug sensitive and in patients with extreme drug-resistance (61.9% vs.
66.7%; P = 0.831). HAI is significantly associated with multi drug resistance of hvKP (odds ratio [OR], 7.917; P < 0.05) and diabetes is associated
with increased risk of hvKP related mortality (OR, 5.250; P = 0.054). Conclusions: Our study results showed, increased incidence of HAI with hvKP
predominantly associated with pneumonia and increase in trend of drug resistance with two cases being pan resistant. More number of studies are
required to evaluate the existing antibiotics strategy and steps to curb the spread of this dreaded infection.