Revista de Otologia e Rinologia

Mucosal Malignant Melanoma of Inferior Concha and Nasal Septum: A Case Report with Mutation Analysis

Ismail Yilmaz, Evren Erkul, Gizem Narli1, Onuralp Kurt, Zafer Kucukodaci, Murat Salihoglu, Ufuk Berber and Dilaver Demirel

Mucosal Malignant Melanoma of Inferior Concha and Nasal Septum: A Case Report with Mutation Analysis

Nasal and paranasal Mucosal Malign Melanoma’s occurs 0.5% of all Malign Melanomas. Sinonasal Mucosal Malign Melanoma often arises from lateral nasal wall and septum. We present molecular features (BRAF, NRAS, c-KIT and PDGFRA mutations) of a sixty-three-year-old male patient with primary sinonasal mucosal malignant melanoma with rarely localized synchronously in inferior concha and nasal septum. The patient underwent melanoma resection via endoscopic approach with negative surgical margins, right functional neck dissection and 6000 Gy radiotherapy after surgery. There was no tumor recurrence and metastasis at the ten month follow-up of the patient. Pathological studies revealed no mutations in the KIT gene (exons 9, 11, 13, 17 and 18), NRAS gene (exons 2 and 3), BRAF gene (exon 15) and the PDGFRA gene (exons 12 and 18) in this tumor. Our case is also unique with its concurrent localization in the nasal septum and inferior turbinate and with no mutations in BRAF, NRAS, c-KIT and PDGFRA genes. Primary sinonasal mucosal malignant melanomas are biologically different from cutaneous malignant melanomas and molecular features of these tumors need more investigation.