Oncologia Clínica: Relatos de Casos

Cancer Therapeutics: Next-Generation Immunotherapy

Carlos A. Cardenas*

Cancer remains a major global health concern, causing significant morbidity and mortality. The evolving field of cancer research has progressed from early detection to effective treatments aimed at decreasing cancer-related deaths. Molecular biology and genetics advancements have deepened our understanding of cancer biology, leading to breakthroughs in treatment approaches. Immunotherapy has emerged as a promising therapeutic option that uses the patient's immune system to combat cancer. Various immunotherapeutic strategies, including immune checkpoint inhibitors, monoclonal antibodies, mRNA vaccines, and CAR-T cell therapies, offer targeted and efficacious therapies with fewer adverse effects compared to traditional chemotherapy. Combination therapies involving immunotherapy and other modalities have demonstrated improved treatment outcomes, providing new avenues for tailored and more effective cancer treatments. Monoclonal antibodies, especially humanized versions, have revolutionized cancer therapeutics by providing high specificity and lower cytotoxicity. The FDA approvals of immunotherapeutic drugs underscore the progress made. Antibody engineering has further advanced the production of specialized and potent humanized monoclonal antibodies for clinical use. Immune checkpoint inhibitors have shown remarkable results in controlling tumor progression. CAR-T cell therapy and cancer vaccines offer targeted treatments, specifically in hematological cancers. Research on neoantigens and personalized vaccines presents new possibilities for more effective cancer treatments. Collaboration between healthcare organizations and researchers is crucial to drive further advancements and reduce the burden of cancer worldwide. While progress is promising, it is essential to approach these advancements with sensitivity and compassion for patients and caregivers, prioritizing self-care, and support. Continued research and development in the field of immunotherapy and other cutting-edge modalities offer hope for improved cancer care and outcomes globally.