Biologia Celular: Pesquisa e Terapia

Clinical Outcomes of Autologous Somatic Stem Cell Therapy in Patients with Traumatic Spinal Cord Injury

Ahmed Bader Aldhulaie, Isa Abdulla Alhadi and Sfoug Alshammary*

Introduction: Spinal cord injury limits the productivity of individuals tremendously, and until recently, management procedures and rehabilitation were the only options. Although stem cell therapy shows a promising potential towards finding a cure for SCI, we try to shed light on the advancements in regenerative medicine and stem cell therapy related to SCI. Methods: The use of autologous somatic stem cells from 19 studies between January 2000 to May 2019, containing 498 patients, was reviewed based on AIS, Bladder functions assessment, and electrophysiological studies. Additionally, changes in the bladder’s function, MRI, walking status, and we noticed some adverse events. Results: More than one-third of patients had improved in general, while only two cases showed deterioration. Following treatment, 7.9% of patients included were able to walk with assistance, 18% of patients had improved bladder functions test, and 34% of patients showed positive changes in MRI. Meanwhile, the most notable adverse effects were minor. Conclusion: Autologous somatic stem cell therapy has a very promising potential for SCI patients, in which they improved in a mild to moderate manner.