Jornal de Pesquisa Farmacêutica e Entrega de Medicamentos

Formulation, Optimization and Evaluation of Atorvastatin Calcium Loaded Microemulsion

Bhumika Sharma, Arvind Sharma, Sandeep Arora, Shriya Gupta and Manila Bishnoi

Formulation, Optimization and Evaluation of Atorvastatin Calcium Loaded Microemulsion

Atorvastatin calcium is a HMG-CoA inhibitor having an Antihyperlipidemic effect. It belongs to the II class of BCS classification hence formulating a microemulsion will increase its solubility/ dissolution and thus improves the oral bioavailability. Microemulsion formulation is prepared by water titration method using Labrafil M1944CS, Cremophor RH 40 and Transcutol HP as oil, surfactant and co-surfactant respectively. A single isotropic region, which is considered to be a bicontinuous microemulsion, is found in the pseudoternary phase diagrams developed at various ratios of Labrafil M1944CS, Cremophor RH 40 and Transcutol HP. The prepared microemulsion formulations are characterised for their thermodynamic stability, drug content, pH, percent transmittance, viscosity, conductivity, particle size determination, TEM analysis and in vitro release.