Revista Internacional de Saúde Mental e Psiquiatria

Melatonin and Schizophrenia: Physiological, Pharmacological and Pathological Approach

Ali Rastqar*, Niraj Patel and Zahra Ghasemzadeh

Schizophrenia includes a wide range of mental disorders that cause social and occupational disabilities, can leads to improper behaviours. Melatonin has not been widely focused on schizophrenic patients. However, the researchers have tried to design the drug to treat, prevent progression of the illness, or at least to minimize its physical and mental subsequent. Efforts for the finding of new approaches or new medications as well as endogen substances, which can improve the disease or even influence to its etiology, will be an outstanding success. Recently, it has proved that melatonin (an endogen neurohormone) can play an important role in various forms from preventing illness onset or can reduce the severity of medications side effects. This review aims to highlight the potential effects of melatonin on multiple aspects of schizophrenia.