Revista de Nanomateriais e Nanotecnologia Molecular

In Vivo Biocompatibility Evaluation of Gelatin�Hydroxyapatite Crosslink Biomimetic Scaffolds for Bone Regeneration

Sorasun Rungsiyanont, Kanako Noritake, Warunee Pluemsakunthai, Somchai Yodsanga, Somporn Swasdison, and Shohei Kasugai

In Vivo Biocompatibility Evaluation of Gelatin–Hydroxyapatite Crosslink Biomimetic Scaffolds for Bone Regeneration

Biomimetic gelatin (gel)/hydroxyapatite (HA) scaffolds have been prepared for bone regeneration and hard tissue engineering. (A) 2.5% gel solely and (B) coprecipitation of 2.5% gel with 2.5% HA (w/w) were prepared to evaluate their biocompatibility, biodegradation and defect shape maintenance for regeneration. Sixteen week-old Vista rats (n=30) were used and calvarial defects were grafted with these scaffolds.