Jornal de Técnicas Imunológicas e Doenças Infecciosas

In Silico Protein Ligand Docking to Study the Effect of Astaxanthin and Colchicine against Human Papilloma Virus Proteins

Rajarshi Das and Seneha Santoshi

Human papilloma virus is a deadly virus that causes cervical, penile and vulval cancer. The current effort focuses on HPV's lesser-known proteins, as well as its virulence and prevalence in men and women. The leitmotif of this study is to create drugs against the proteins of the Human papilloma Virus as a suggestive solution against the diseases caused by this virus. The study includes the extraction of the protein sequences of the virus from NCBI, followed with the secondary structure prediction with the aid of the usage of online available protein prediction tools; GOR4, Chou, Fasman and Phyre2. Homology modelling using SWISSMODEL was done of each protein (E1, E2, L1 and L2) taken from HPV for receiving the appropriate model for the respective proteins. The PDB files for each of the protein were downloaded and used for docking against respective ligands mentioned in this review. The docking results are elaborately discussed in this study.