Jornal de Bioinformática Aplicada e Biologia Computacional

Missing Data: A Non-ignorable Issue in Modern Biostatistics

Baojiang Chen and Kendra K. Schmid

Missing Data: A Non-ignorable Issue in Modern Biostatistics

Missing data is a common feature in modern biostatistics. For most cases, the easily implemented method such as complete case analysis will yield biased conclusions if data are Missing At Random (MAR) or Missing Not At Random (MNAR). The vast majority of articles in the literature dealing with incomplete data make the unrealistic assumption that data are available for the response but incomplete for the covariates or risk factors, or alternatively, they assume that information on risk factors is complete, but the data on response are incomplete.