Jornal Internacional de Pesquisa Cardiovascular

Psychiatric Disorders In Takotsubo Cardiomyopathy Compared With Acute Coronary Syndrome Patients

Fabrizio Ugo, Mario Iannaccone, Fabrizio D’Ascenzo, Ovidio De Filippo, Dario Celentani, Davide Lazzeroni, Luca Moderato, Francesco Saggese, Silvia Mazzilli, Nicola Gaibazzi, Claudio Moretti, Diego Ardissino, Fiorenzo Gaita and Paolo Coruzzi

Introduction: Depression and anxiety represent a common pathway for patients presenting with Takotsubo Cardiomyopathy (TTC) and Acute Coronary Syndrome (ACS) although differences in prevalence and their potential relation to cardiac disease onset remain to be described. Method and Results: 41 consecutive female patients with diagnosis of TTC were prospectively enrolled and compared with 82 consecutive age/sex matched patients with ACS as control group in a 1:2 fashion. Prevalence of psychological disorder was significantly higher in TTC patients compared with ACS (49% vs 26% p=0.01). In the subgroup with psychological disease, patients with TTC were more often anxious, while patients with ACS were more often affected by depression (80% vs 38% and 15% vs 48% respectively, p=0.02). At multiple regres-sion analysis TTC was an independent predictor of psychiatric disorders (HR 1.28 CI 1.1-1.5, p<0.01). Conclusion: In a cohort of elderly women with TTC, the prevalence of psychological disease is higher and with oppo-site clinical features (anxious vs depressed) compared with a matched ACS cohort.