Jornal Internacional de Pesquisa Cardiovascular

Troponin and Tropomyosin in the Cardiomyocyte Nucleus:What for?

Faizal Z. Asumda

 Troponin and Tropomyosin in the Cardiomyocyte Nucleus:What for?

A number of recent reports have shown the nuclear expression of troponin and tropomyosin in cardiac myocytes. This challenges the long standing view that these sarcomere proteins are physiologically restricted to the cytoplasm. A synthesis of the available data suggests that troponin and tropomyosin in the cell nucleus is not the result of cytoplasmic contamination. The data is suggestive of physiological roles outside their well-recognized function in excitation-contraction coupling.